Comparison of IL-10 gene promoter polymorphisms and haplotypes between high-grade squamous intraepithelial lesions or cervical cancer and negative cervical cytology

Comparison of IL-10 gene promoter polymorphisms and haplotypes between high-grade squamous intraepithelial lesions or cervical cancer and negative cervical cytology

Abstract Cervical cancer, a leading cancer among women, is strongly associated with Human Papillomavirus infection, but host genetic factors also contribute to the progression from high-grade squamous intraepithelial lesions (HSIL) to invasive cancer. Interleukin-10 (IL-10), an immunosuppressive cyt...

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Main Authors: Amaxsell Thiago Barros de Souza, Deborah Luisa de Sousa Santos, Fernanda Silva Medeiros, Kleyton Thiago Costa de Carvalho, George Alexandre Lira, Ricardo Ney Cobucci, Kassio Michell Gomes de Lima, Norma Lucena-Silva, Eduardo Antônio Donadi, Janaina Cristiana de Oliveira Crispim
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Interleukin-10
Polymorphism, single nucleotide
Uterine cervical neoplasms
Online Access:https://doi.org/10.1038/s41598-025-12851-5
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https://doi.org/10.1038/s41598-025-12851-5

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