Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report

Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report

The treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to the drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) is an orally small molecule agents target SARS-CoV-2 RdRp and inhibits viral replication. I...

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Bibliographic Details
Main Authors: Jiaying Zhang, Yuan Gao, Xiaoyun Miao, Wei Wang, Zhongkai Zhou, Yunyi Gao, Liwei Liu, Menghua Wu, Ke Ma, Ling Zhou, Yan Yang, Sha Meng, Yingmei Feng, Zhuorui Zhao, Wei Liu, Danlei Mou, Zixin Kang, Lianchun Liang, Zhongjie Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
COVID-19
organ transplant
kidney dysfunction
drug accumulation
VV116
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501813/full
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