Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin

Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin

Abstract Background Bleomycin (Bleo) is a glycopeptide with potent antitumor activity that induces DNA double-strand breaks (DSBs) through free radical generation, similar to ionizing radiation (IR). Therefore, Bleo is considered a radiomimetic drug. However, differences in DNA repair mechanisms bet...

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Bibliographic Details
Main Authors: Naoto Shimizu, Kazuki Izawa, Mubasshir Washif, Ryosuke Morozumi, Kouji Hirota, Masataka Tsuda
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genes and Environment
Subjects:
Radiomimetic drugs
Bleomycin
Ionizing radiation
DNA double-strand breaks
TK6
Tyrosyl-DNA phosphodiesterase
Online Access:https://doi.org/10.1186/s41021-025-00329-9
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https://doi.org/10.1186/s41021-025-00329-9

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