The P4HB/LGALS3BP/NF-kB axis promotes the progression of MIA to IAC in lung adenocarcinoma

The P4HB/LGALS3BP/NF-kB axis promotes the progression of MIA to IAC in lung adenocarcinoma

Abstract Prolyl 4-hydroxylase β-subunit (P4HB) is a class of molecular chaperones that inhibits the misfolding of endoplasmic reticulum proteins, and its role in microinvasive adenocarcinoma (MIA) progresses to invasive adenocarcinoma (IAC) is currently unclear. We mined the single-cell dataset GSE1...

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Bibliographic Details
Main Authors: Guang Mu, Wenhao Zhang, Yan Gu, Hongchang Wang, Jingjing Huang, Chengyu Bian, Ke Wei, Yang Xia, Jun Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Lung adenocarcinoma
P4HB
LGALS3BP
NF-kB
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-12661-9
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https://doi.org/10.1038/s41598-025-12661-9

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