Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes

Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes

Abstract Ubiquitination is the key eukaryotic post-translational modification that governs protein degradation, localisation, and activity which is mediated by a concerted enzyme cascade. The largest superfamily of these enzymes include the Cullin-RING-Ligase (CRL) complexes. Plasmodium falciparum,...

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Main Authors: Danushka Marapana, Simon A. Cobbold, Michal Pasternak, Gerald J. Shami, Stuart A. Ralph, Sash Lopaticki, Jumana Yousef, Vineet Vaibhav, Laura F. Dagley, David Komander, Alan F. Cowman
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Malaria
E3 ligase
Cullin-ring-ligase
P. falciparum
Ubiquitination
Online Access:https://doi.org/10.1038/s41598-025-05342-0
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https://doi.org/10.1038/s41598-025-05342-0

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