Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy

Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy

Abstract Background Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease and undertreatment of aggressive cases. Results Through whole-exome sequencing of 147 DCIS...

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Main Authors: Noor Rizvi, Eliseos J. Mucaki, Emily L. Salmini, Monica Zhang, Sabina Trebinjac, Ezra Hahn, Lawrence Paszat, Sharon Nofech-Mozes, Michael T. Hallett, Eileen Rakovitch, Vanessa Dumeaux
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Online Access:https://doi.org/10.1186/s13058-025-02080-z
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https://doi.org/10.1186/s13058-025-02080-z

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