Downregulation of ubiquitous microRNA-320 in hepatocytes triggers RFX1-mediated FGF1 suppression to accelerate MASH progression

Downregulation of ubiquitous microRNA-320 in hepatocytes triggers RFX1-mediated FGF1 suppression to accelerate MASH progression

Metabolic dysfunction-associated steatohepatitis (MASH), a severe type of metabolic dysfunction-associated steatotic liver disease (MASLD), is a leading etiology of end-stage liver disease worldwide, posing significant health and economic burdens. microRNA-320 (miR-320), a ubiquitously expressed and...

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Bibliographic Details
Main Authors: Liu Yang, Wenjun Li, Yingfen Chen, Ru Ya, Shengying Qian, Li Liu, Yawen Hao, Qiuhong Zai, Peng Xiao, Seonghwan Hwang, Yong He
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
miR-320
MASLD
RFX1
FGF1
AMPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525004101
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