HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models

HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models

Abstract Defects at the neuromuscular junction (NMJ) are among the earliest hallmarks of amyotrophic lateral sclerosis (ALS). According to the “dying-back” hypothesis, NMJ disruption not only precedes but also triggers the subsequent degeneration of motoneurons in both sporadic (sALS) and familial (...

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Main Authors: Beatrice Silvestri, Michela Mochi, Darilang Mawrie, Valeria de Turris, Alessio Colantoni, Beatrice Borhy, Margherita Medici, Eric Nathaniel Anderson, Maria Giovanna Garone, Christopher Patrick Zammerilla, Marco Simula, Monica Ballarino, Udai Bhan Pandey, Alessandro Rosa
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54004-8
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https://doi.org/10.1038/s41467-024-54004-8

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