Ascorbate peroxidase modulation confirms key role in Leishmania infantum oxidative defence

Ascorbate peroxidase modulation confirms key role in Leishmania infantum oxidative defence

Abstract Background Ascorbate peroxidase (APX) has emerged as a promising target for chemotherapy because of its absence in humans and crucial role in the antioxidant defence of trypanosomatids. APXs, which are class I haeme-containing enzymes, reduces hydrogen peroxide using ascorbate to produce wa...

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Bibliographic Details
Main Authors: Isabella Fernandes Martins Santos, Douglas de Souza Moreira, Karla Ferreira Costa, Juliana Martins Ribeiro, Silvane Maria Fonseca Murta, Ana Maria Murta Santi
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Parasites & Vectors
Subjects:
Leishmania infantum
Ascorbate peroxidase
CRISPR/Cas9
Antioxidant defence
Drug resistance
Online Access:https://doi.org/10.1186/s13071-024-06562-5
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https://doi.org/10.1186/s13071-024-06562-5

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