The question of strains in AA amyloidosis

The question of strains in AA amyloidosis

Abstract The existence of transmissible amyloid fibril strains has long intrigued the scientific community. The strain theory originates from prion disorders, but here, we provide evidence of strains in systemic amyloidosis. Human AA amyloidosis manifests as two distinct clinical phenotypes called c...

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Bibliographic Details
Main Authors: Gunilla T. Westermark, Ebba Nyström, Sofie Nyström, K. Peter R. Nilsson, Per Hammarström, Per Westermark
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Fluorescent amyloid ligands
Amyloid transmission
Prion
Protein aggregation
Amyloid strains
Online Access:https://doi.org/10.1038/s41598-025-87239-6
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