Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells

Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells

Abstract Background Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regulatory functions of TRM cel...

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Bibliographic Details
Main Authors:	Yimei Lai, Lili Zhuang, Jieying Zhu, Shuang Wang, Chaohuan Guo, Binfeng Chen, Jin Li, Jia Shi, Mengyuan Li, Niansheng Yang, Mianjing Zhou
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	Journal of Translational Medicine
Subjects:	Lupus nephritis NLRP3 inflammasome CD8+ tissue-resident memory cells IL-1β
Online Access:	https://doi.org/10.1186/s12967-024-05951-9
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