Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells

Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells

Abstract Background Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regulatory functions of TRM cel...

Full description

Saved in:
Bibliographic Details
Main Authors: Yimei Lai, Lili Zhuang, Jieying Zhu, Shuang Wang, Chaohuan Guo, Binfeng Chen, Jin Li, Jia Shi, Mengyuan Li, Niansheng Yang, Mianjing Zhou
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Lupus nephritis
NLRP3 inflammasome
CD8+ tissue-resident memory cells
IL-1β
Online Access:https://doi.org/10.1186/s12967-024-05951-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-024-05951-9

Similar Items