Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases

Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases

Abstract Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many of the seemingly disparate physiological functions that are damaged in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia (FTD) and amyotrophic lateral sclerosi...

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Bibliographic Details
Main Authors: Kerry Blair, Raquel Martinez-Serra, Philippe Gosset, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Joseph Atherton, Jacqueline C. Mitchell, Andrea Markovinovic, Christopher C. J. Miller
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Acta Neuropathologica Communications
Subjects:
Neurodegenerative diseases
Frontotemporal dementia
Amyotrophic lateral sclerosis
Alzheimer’s disease
Parkinson’s disease
Online Access:https://doi.org/10.1186/s40478-025-01964-7
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https://doi.org/10.1186/s40478-025-01964-7

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