Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review]
Typhoid intestinal perforation (TIP) is a life-threatening, late complication of typhoid fever that disproportionately impacts children in low resource settings and continues to have devastating consequences worldwide. Despite elimination of typhoid fever in most high income countries, typhoid fever...
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F1000 Research Ltd
2025-05-01
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| Online Access: | https://gatesopenresearch.org/articles/9-16/v1 |
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| author | Ide Kadi Amadou Magagi Ibrahim Abdou Soley Aboul Aziz Zabeirou Oudou Abdou Aliou Mahamadou Doutchi Altine Boubacar Moctar Adehossi Eric Brah Souleymane Mamadou Saidou Joseph Emalieu Toko Lassane Kabore Assan Abdoul Nasser Rachid Sani Kathleen Neuzil Harissou Adamou Yakoubou Sanoussi Abdoulaye Maman Bachir Leah Sukri Katherine Shafer Saidou Adama Laura Hobbs |
| author_facet | Ide Kadi Amadou Magagi Ibrahim Abdou Soley Aboul Aziz Zabeirou Oudou Abdou Aliou Mahamadou Doutchi Altine Boubacar Moctar Adehossi Eric Brah Souleymane Mamadou Saidou Joseph Emalieu Toko Lassane Kabore Assan Abdoul Nasser Rachid Sani Kathleen Neuzil Harissou Adamou Yakoubou Sanoussi Abdoulaye Maman Bachir Leah Sukri Katherine Shafer Saidou Adama Laura Hobbs |
| author_sort | Ide Kadi |
| collection | DOAJ |
| description | Typhoid intestinal perforation (TIP) is a life-threatening, late complication of typhoid fever that disproportionately impacts children in low resource settings and continues to have devastating consequences worldwide. Despite elimination of typhoid fever in most high income countries, typhoid fever and TIP remain endemic in many countries around the world as a result of inadequate investments in water, sanitation, and hygiene (WASH) and lack of access to vaccines. A first National Typhoid Conference was held in Niamey, Niger on July 22, 2023, where surgeons and other medical and health professionals from Niger convened with local and international health professionals to discuss their experiences with TIP and advocate for better prevention and treatment of the disease. The high number of intestinal perforations diagnosed during surgery, and the lack of capacity for performing blood cultures motivated surgeons in Niger to convene and share data on complications of typhoid, epidemiology, and diagnosis. TIP, a leading cause of peritonitis in Africa, often results in emergency surgery and has reported mortality rates up to 30% in pediatric patients. The availability of four safe and effective typhoid conjugate vaccines, two with committed financial support from Gavi, the Vaccine Alliance, makes prevention through vaccination a realistic near-option for typhoid fever to complement improvements in WASH. |
| format | Article |
| id | doaj-art-8d27dee732b84b0c8286d0a564d0e64a |
| institution | Kabale University |
| issn | 2572-4754 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | Gates Open Research |
| spelling | doaj-art-8d27dee732b84b0c8286d0a564d0e64a2025-08-20T03:48:58ZengF1000 Research LtdGates Open Research2572-47542025-05-01910.12688/gatesopenres.16348.117747Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review]Ide Kadi0Amadou Magagi Ibrahim1Abdou Soley Aboul Aziz2Zabeirou Oudou Abdou Aliou3Mahamadou Doutchi Altine4Boubacar Moctar5Adehossi Eric6Brah Souleymane7Mamadou Saidou8Joseph Emalieu Toko9Lassane Kabore10Assan Abdoul Nasser11Rachid Sani12Kathleen Neuzil13Harissou Adamou14Yakoubou Sanoussi15Abdoulaye Maman Bachir16Leah Sukri17Katherine Shafer18Saidou Adama19Laura Hobbs20Hôpital National de Niamey, Niamey, NigerHôpital National de Zinder, Zinder, NigerCentre Hospitalier Régional, Tahoua, NigerHôpital Général De Reférence, Niamey, NigerHôpital National de Zinder, Zinder, NigerCentre Hospitalier Régional, Maradi, NigerHôpital Général De Reférence, Niamey, NigerHôpital National Amirou Boubacar Diallo, Niamey, NigerUniversité Abdou Moumouni de Niamey, Niamey, NigerUniversity of Yaounde, Soa, CameroonCenter for Vaccine Innovation and Access, PATH, Seattle, Washington, 98121, USAMinistry of Public Health, Population and Social Affairs, Niamey, NigerHôpital National de Niamey, Niamey, NigerUniversity of Maryland Baltimore, Baltimore, Maryland, 21201, USAHôpital National de Zinder, Zinder, NigerHôpital de la SIM, Galmi, NigerHôpital National de Niamey, Niamey, NigerUniversity of Maryland Baltimore, Baltimore, Maryland, 21201, USAHôpital de la SIM, Galmi, NigerHôpital Général De Reférence, Niamey, NigerUniversity of Maryland Baltimore, Baltimore, Maryland, 21201, USATyphoid intestinal perforation (TIP) is a life-threatening, late complication of typhoid fever that disproportionately impacts children in low resource settings and continues to have devastating consequences worldwide. Despite elimination of typhoid fever in most high income countries, typhoid fever and TIP remain endemic in many countries around the world as a result of inadequate investments in water, sanitation, and hygiene (WASH) and lack of access to vaccines. A first National Typhoid Conference was held in Niamey, Niger on July 22, 2023, where surgeons and other medical and health professionals from Niger convened with local and international health professionals to discuss their experiences with TIP and advocate for better prevention and treatment of the disease. The high number of intestinal perforations diagnosed during surgery, and the lack of capacity for performing blood cultures motivated surgeons in Niger to convene and share data on complications of typhoid, epidemiology, and diagnosis. TIP, a leading cause of peritonitis in Africa, often results in emergency surgery and has reported mortality rates up to 30% in pediatric patients. The availability of four safe and effective typhoid conjugate vaccines, two with committed financial support from Gavi, the Vaccine Alliance, makes prevention through vaccination a realistic near-option for typhoid fever to complement improvements in WASH.https://gatesopenresearch.org/articles/9-16/v1Typhoid typhoid intestinal perforation complication Africa Niger typhoid conjugate vaccineeng |
| spellingShingle | Ide Kadi Amadou Magagi Ibrahim Abdou Soley Aboul Aziz Zabeirou Oudou Abdou Aliou Mahamadou Doutchi Altine Boubacar Moctar Adehossi Eric Brah Souleymane Mamadou Saidou Joseph Emalieu Toko Lassane Kabore Assan Abdoul Nasser Rachid Sani Kathleen Neuzil Harissou Adamou Yakoubou Sanoussi Abdoulaye Maman Bachir Leah Sukri Katherine Shafer Saidou Adama Laura Hobbs Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review] Gates Open Research Typhoid typhoid intestinal perforation complication Africa Niger typhoid conjugate vaccine eng |
| title | Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review] |
| title_full | Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review] |
| title_fullStr | Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review] |
| title_full_unstemmed | Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review] |
| title_short | Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger [version 1; peer review: awaiting peer review] |
| title_sort | surgical complications of typhoid fever first national typhoid conference in niamey niger version 1 peer review awaiting peer review |
| topic | Typhoid typhoid intestinal perforation complication Africa Niger typhoid conjugate vaccine eng |
| url | https://gatesopenresearch.org/articles/9-16/v1 |
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