Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Abstract Small cell lung cancer (SCLC) is an extremely aggressive and highly malignant type of lung cancer that frequently develops resistance and recurrence following initial treatment. Paclitaxel (PTX) is a second‐line therapeutic option for SCLC patients with resistance to first‐line treatment. H...

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Bibliographic Details
Main Authors: Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
ferroptosis
immunotherapy
PFKFB4
Small cell lung cancer
tumor immune microenvironment
Online Access:https://doi.org/10.1002/advs.202417374
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https://doi.org/10.1002/advs.202417374

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