Total glucosides of paeony ameliorates chemotherapy-induced neuropathic pain by suppressing microglia pyroptosis through the inhibition of KAT2A-mediated p38 pathway activation and succinylation

Total glucosides of paeony ameliorates chemotherapy-induced neuropathic pain by suppressing microglia pyroptosis through the inhibition of KAT2A-mediated p38 pathway activation and succinylation

Abstract Chemotherapy-induced neuropathic pain (CINP) is a prevalent side effect of chemotherapy. Total glucosides of paeony (TGP) have been shown to be effective in pain management. This study aimed to investigate the efficacy and mechanism of TGP in alleviating CINP. Sprague–Dawley rats were treat...

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Bibliographic Details
Main Authors: Rong Chen, Jiantao Hu, Yang Zhang, Yang Liu, Jingsong Zhu, Zheng Pan, Hua Yang, Qin Wang, Ying Chen, Songjiang Tang, Baojun Min
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Chemotherapy-induced neuropathic pain
Total glucosides of paeony
Pyroptosis
Succinylation
KAT2A
Online Access:https://doi.org/10.1038/s41598-024-83207-8
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