Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells

Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells

Abstract Background Liver fibrosis is a complex reparative process in response to chronic liver injuries, with limited effective therapeutic options available in clinical practice. During liver fibrosis, liver sinusoidal endothelial cells (LSECs) undergo phenotypic changes and also play a role in mo...

Full description

Saved in:

Bibliographic Details
Main Authors:	Le Wang, Jiaorong Qu, Jianan Li, Xiaoyong Xue, Lingling Qin, Yufei Li, Yuanfeng Dou, Xiaohong Mu, Xiaojiaoyang Li
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	Chinese Medicine
Subjects:	Si-Wu-Tang Liver fibrosis Liver sinusoidal endothelial cell Angiogenesis Cell adhesion Defenestration
Online Access:	https://doi.org/10.1186/s13020-024-01038-1
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance
by: Kimberly N. Kremer, et al.
Published: (2025-01-01)

Protection of liver sinusoidal endothelial cells using different preservation solutions
by: Julia H E Houtzager, et al.
Published: (2025-02-01)

Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells
by: Wenshuai Li, et al.
Published: (2025-02-01)

Spinal cord injury induces transient activation of hepatic stellate cells in rat liver
by: Inmaculada Fernandez-Canadas, et al.
Published: (2025-01-01)

The liver’s dilemma: sensing real danger in a sea of PAMPs: the (arterial) sinusoidal segment theory
by: Andrea Henriques-Pons, et al.
Published: (2025-01-01)

Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk
by: Ling‐Feng Zhang, et al.
Published: (2025-01-01)

Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation
by: Jianli Qiu, et al.
Published: (2025-02-01)

Reconstitution Properties of Thymus Stem Cells in Murine Fetal Liver
by: Hilary J. Mckenna, et al.
Published: (1994-01-01)

Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway
by: Guanqi Dai, et al.
Published: (2025-01-01)

Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure
by: Zhuoran Wang, et al.
Published: (2025-02-01)

Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction
by: Thuy Linh Lai, et al.
Published: (2024-12-01)

A General Overview of Mesenchymal Stem Cell Therapies in Drug- and Chemical-Induced Liver Injury Models
by: Müşerref Şeyma Ceyhan, et al.
Published: (2024-04-01)

Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess
by: Sandhya Khunger, et al.
Published: (2025-03-01)

Advances in liver engineering with cell, scaffold, and vascularization
by: Chunyan Liu, et al.
Published: (2024-12-01)

Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance
by: Ji Won Han, et al.
Published: (2024-12-01)

Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells
by: Yujing Tao, et al.
Published: (2025-01-01)

Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies
by: Pallavi Prasad, et al.
Published: (2023-07-01)

The perspectives of autologous hepatocytes generation for the treatment of liver failure
by: M. N. Evseeva, et al.
Published: (2015-12-01)

Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis
by: Georgiana-Iulia Lupu, et al.
Published: (2024-12-01)

Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis
by: Hui Liu, et al.
Published: (2024-11-01)

Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials
by: Wei-Chen Huang, et al.
Published: (2025-01-01)

Application of the HeWuTong System in the Practice of the “River Chief System”
by: TAO Tao, et al.
Published: (2020-01-01)

Protocol for isolating and purifying murine liver sinusoidal endothelial cells for in vitro culture and functional assays
by: Sophia Papaioannou, et al.
Published: (2025-03-01)

Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer
by: Linlin Lou, et al.
Published: (2025-01-01)

Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever
by: Yizhen Yuan, et al.
Published: (2025-01-01)

Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review
by: Jong Ryeol Eun
Published: (2025-01-01)

Mesenchymal stem cell and exosome-based therapy for liver diseases: can it overcome conventional therapeutic inconsistencies?
by: Zahid Hussain
Published: (2025-01-01)

The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver
by: Hiroyuki Nakashima, et al.
Published: (2024-12-01)

SOME IDEAS ABOUT JAR-REBURIAL CUSTOM OF TAY, HOA, NUNG, THAI INHABITANTS IN LIENNGHIA TOWN, DUCTRONG DISTRICT, LAMDONG PROVINCE, VIETNAM
by: Cao Thế Trình
Published: (2018-12-01)

Liver macrophage activation: Relation with hepatic histopathological changes in patients with metabolic associated steatotic liver disease
by: Doaa H. Hegazy, et al.
Published: (2024-06-01)

Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease
by: Edwin A Homan, et al.
Published: (2025-01-01)

The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease
by: Shaoqiang Wu, et al.
Published: (2025-01-01)

Tooth Profile Synthesis and Meshing Force Characteristic of Sinusoidal Double Generating-wave Pushrod Movable Tooth Transmission
by: Wang Lichuang, et al.
Published: (2020-02-01)

Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study
by: Ying Di, et al.
Published: (2024-08-01)

Detection of reproducible liver cancer specific ligand-receptor signaling in blood
by: Aram Safrastyan, et al.
Published: (2025-01-01)

Study on Pharmacodynamic Material Basis and Molecular Mechanism of Wutou Tang in Pain Relief Based on Computer Simulation
by: Chunsong ZHENG, et al.
Published: (2016-02-01)

Evaluation of Liver Fibrosis through Noninvasive Tests in Steatotic Liver Disease
by: Yuri Cho
Published: (2024-11-01)

Mathematical modeling of liver fibrosis
by: Avner Friedman, et al.
Published: (2017-01-01)

LIVER DISEASE & SICKLE CELL DISEASE: AUTOIMMUNE HEPATITIS MORE THAN A COINCIDENCE; A SYSTEMATIC LITERATURE REVIEW.
by: Kelvin Lynch, et al.
Published: (2023-10-01)

Epstein–Barr virus-positive inflammatory follicular dendritic cell sarcoma of the liver: A case report
by: Jong-Shiaw Jin, et al.
Published: (2024-12-01)