Assessment of CD73 activity in breast cancer-derived small extracellular vesicles: application to monitoring of patients’ responses to immunotherapy

Background: We previously discovered that small extracellular vesicles (sEV) isolated from melanoma cells produce immunosuppressive adenosine (ADO) via the ATP→ADP→AMP→ADO pathway and that CD73 is the ‘gateway’ ecto-nucleotidase used by melanoma sEV to generate ADO. Here we extend these findings to...

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Bibliographic Details
Main Authors: T.L. Whiteside, S. Sehra, T. Chadderton, M. Guha, M.C. Stubbs, C. Timmers, E.K. Jackson
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Immuno-Oncology and Technology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2590018825000127
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