Collateral susceptibility-guided alternation of ceftolozane/tazobactam with imipenem prevents resistance development in XDR Pseudomonas aeruginosa biofilms

Collateral susceptibility-guided alternation of ceftolozane/tazobactam with imipenem prevents resistance development in XDR Pseudomonas aeruginosa biofilms

Objectives: New combinations of β-lactams and β-lactamase inhibitors, such as ceftolozane/tazobactam could be useful to combat biofilm-driven chronic infections by extensively resistant (XDR) Pseudomonas aeruginosa but resistance development by mutations in the Ω-loop of AmpC has been described. How...

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Bibliographic Details
Main Authors: María Fernández-Billón, Elena Jordana-Lluch, Aina E. Llambías-Cabot, María A. Gomis-Font, Pablo Fraile-Ribot, Rosa I. Torrandell, Pamela J. Colman-Vega, Óscar Murillo, María D. Macià, Antonio Oliver
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biofilm
Subjects:
Pseudomonas aeruginosa
XDR
Biofilms
Antagonistic resistance mechanisms to antibiotics
Online Access:http://www.sciencedirect.com/science/article/pii/S259020752400056X
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