Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats
Objective: Myristica fragrans, a common kitchen spice, is reported to have psychoactive properties, producing hallucinations and fear. The psychoactive action is attributed to the presence of myristicin. This study aimed to assess the effects of ethanol seed extract of Myristica fragrans (ESMF) on...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Babcock Medical Society
2024-12-01
|
| Series: | Babcock University Medical Journal |
| Subjects: | |
| Online Access: | http://bumj.babcock.edu.ng/index.php/bumj/article/view/399 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558927993470976 |
|---|---|
| author | SUNDAY Abba SUNDAY ABRAHAM MUSA Abel Agbon SUNDAY OLADELE IBRAHIM Joseph Momoh ENYINNA OGBONNA OLUSEGUN Dare Omotosho |
| author_facet | SUNDAY Abba SUNDAY ABRAHAM MUSA Abel Agbon SUNDAY OLADELE IBRAHIM Joseph Momoh ENYINNA OGBONNA OLUSEGUN Dare Omotosho |
| author_sort | SUNDAY Abba |
| collection | DOAJ |
| description |
Objective: Myristica fragrans, a common kitchen spice, is reported to have psychoactive properties, producing hallucinations and fear. The psychoactive action is attributed to the presence of myristicin. This study aimed to assess the effects of ethanol seed extract of Myristica fragrans (ESMF) on anxiety-like behaviour and dopamine levels in rats.
Materials and Methods: Thirty-six male Wistar rats were divided into six groups of six rats each. Groups I (control, received 2 ml/kg distilled water); Group II (received 2 ml/kg of tween 80 Oil); Groups III, IV and V received ESMF (500 mg/kg; 1000 mg/kg and 1500 mg/kg, respectively) and group VI received methylphenidate (1 mg/kg) as standard stimulant. All administration was done orally for 28 days. The rats were subjected to neurobehavioral tests: an open field test to assess hyperactivity and an elevated plus maze to assess anxiety-like behaviour. Brain samples were harvested and homogenized for neurochemical analysis of dopamine using a dopamine kit.
Results: Hyperactivity was observed as increased line crossing and total distance travelled in the ESMF (500mg/kg)-treated group when compared with the control group and reduced anxiety-like behaviour by reduced frequent close arm entry and duration. Dopamine levels were reduced in the 1500 mg/kg ESMF-treated group compared to the control.
Conclusion: Exposure to ethanol seed extract of Myristica fragrans elicited anxiety-like behaviour. ESMF at a dose of 500mg/kg possesses anxiolytic properties, while at a dose of 1500 mg/kg; elicits anxiety by a reduction in dopamine levels in rats.
|
| format | Article |
| id | doaj-art-8ba769197a93410c8396bb74c5f549ce |
| institution | Kabale University |
| issn | 2465-6666 2756-4657 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Babcock Medical Society |
| record_format | Article |
| series | Babcock University Medical Journal |
| spelling | doaj-art-8ba769197a93410c8396bb74c5f549ce2025-01-05T18:31:39ZengBabcock Medical SocietyBabcock University Medical Journal2465-66662756-46572024-12-017210.38029/babcockuniv.med.j..v7i2.399Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in RatsSUNDAY Abba0SUNDAY ABRAHAM MUSA1Abel Agbon2SUNDAY OLADELE3IBRAHIM Joseph Momoh4ENYINNA OGBONNA5OLUSEGUN Dare Omotosho6Department of Human Anatomy, Prince Abubakar University, Anyigba, NigeriaNeuroanatomy and Neurosciences Research Unit, Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University (ABU), Zaria, NigeriaNeuroanatomy and Neurosciences Research Unit, Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University (ABU), Zaria, NigeriaDepartment of Veterinary Pathology, Faculty of Veterinary Medicine, ABU, Zaria, NigeriaDepartment of Human Physiology, Prince Abubakar University, Anyigba, NigeriaDepartment of Pharmacology, Prince Abubakar University, Anyigba, NigeriaDepartment of Human Anatomy, Prince Abubakar University, Anyigba, Nigeria Objective: Myristica fragrans, a common kitchen spice, is reported to have psychoactive properties, producing hallucinations and fear. The psychoactive action is attributed to the presence of myristicin. This study aimed to assess the effects of ethanol seed extract of Myristica fragrans (ESMF) on anxiety-like behaviour and dopamine levels in rats. Materials and Methods: Thirty-six male Wistar rats were divided into six groups of six rats each. Groups I (control, received 2 ml/kg distilled water); Group II (received 2 ml/kg of tween 80 Oil); Groups III, IV and V received ESMF (500 mg/kg; 1000 mg/kg and 1500 mg/kg, respectively) and group VI received methylphenidate (1 mg/kg) as standard stimulant. All administration was done orally for 28 days. The rats were subjected to neurobehavioral tests: an open field test to assess hyperactivity and an elevated plus maze to assess anxiety-like behaviour. Brain samples were harvested and homogenized for neurochemical analysis of dopamine using a dopamine kit. Results: Hyperactivity was observed as increased line crossing and total distance travelled in the ESMF (500mg/kg)-treated group when compared with the control group and reduced anxiety-like behaviour by reduced frequent close arm entry and duration. Dopamine levels were reduced in the 1500 mg/kg ESMF-treated group compared to the control. Conclusion: Exposure to ethanol seed extract of Myristica fragrans elicited anxiety-like behaviour. ESMF at a dose of 500mg/kg possesses anxiolytic properties, while at a dose of 1500 mg/kg; elicits anxiety by a reduction in dopamine levels in rats. http://bumj.babcock.edu.ng/index.php/bumj/article/view/399NutmegAlterationsMyristicinAnxietyStimulant |
| spellingShingle | SUNDAY Abba SUNDAY ABRAHAM MUSA Abel Agbon SUNDAY OLADELE IBRAHIM Joseph Momoh ENYINNA OGBONNA OLUSEGUN Dare Omotosho Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats Babcock University Medical Journal Nutmeg Alterations Myristicin Anxiety Stimulant |
| title | Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats |
| title_full | Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats |
| title_fullStr | Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats |
| title_full_unstemmed | Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats |
| title_short | Oral Administration of Ethanol Extract of Myristica fragrans Elicited Hyperactivity, Anxiety and Reduced Dopamine Level in Rats |
| title_sort | oral administration of ethanol extract of myristica fragrans elicited hyperactivity anxiety and reduced dopamine level in rats |
| topic | Nutmeg Alterations Myristicin Anxiety Stimulant |
| url | http://bumj.babcock.edu.ng/index.php/bumj/article/view/399 |
| work_keys_str_mv | AT sundayabba oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats AT sundayabrahammusa oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats AT abelagbon oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats AT sundayoladele oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats AT ibrahimjosephmomoh oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats AT enyinnaogbonna oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats AT olusegundareomotosho oraladministrationofethanolextractofmyristicafragranselicitedhyperactivityanxietyandreduceddopaminelevelinrats |