Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis
Abstract Background Given the essential role of cardiometabolic risk factors in the global burden of chronic diseases, this study aimed to assess the potential of cornelian cherry(Cornus mas L.) in improving anthropometric parameters, lipid profile, glycemic indices, liver enzyme levels, and dietary...
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BMC
2025-08-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-025-00991-4 |
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| author | Morteza Omrani Mostafa Norouzzadeh Hamid Ahmadirad Mehrnaz Abbasi Mitra Kazemi Jahromi Farshad Teymoori Minoo Hasan Rashedi Seyedeh Tayebeh Rahideh Hossein Farhadnejad Parvin Mirmiran Mohsen Khaleghian |
| author_facet | Morteza Omrani Mostafa Norouzzadeh Hamid Ahmadirad Mehrnaz Abbasi Mitra Kazemi Jahromi Farshad Teymoori Minoo Hasan Rashedi Seyedeh Tayebeh Rahideh Hossein Farhadnejad Parvin Mirmiran Mohsen Khaleghian |
| author_sort | Morteza Omrani |
| collection | DOAJ |
| description | Abstract Background Given the essential role of cardiometabolic risk factors in the global burden of chronic diseases, this study aimed to assess the potential of cornelian cherry(Cornus mas L.) in improving anthropometric parameters, lipid profile, glycemic indices, liver enzyme levels, and dietary intake of energy and macronutrients. Methods We conducted a systematic search of PubMed, Scopus, Web of Science, and the Cochrane Library for eligible randomized controlled trials(RCTs) published up to May 2025, with no restrictions on language or publication date. The weighted mean difference(WMD) and 95% confidence interval(95%CI) for each outcome were determined using a random-effects model. The certainty of the assessments was further examined using the GRADE assessment. Results Seven RCTs were included in the final analysis. Pooled effect size showed that Cornus mas L(CM) intake significantly reduced body weight (MD:-0.57 Kg,95%CI:-1.03,-0.12;P = 0.013), body mass index(MD:-0.38 kg/m2,95%CI:-0.52,-0.23;P = 0.001), fat mass (MD:-0.97%,95%CI:-1.53,-0.41;P = 0.001), waist circumference (MD:-1.36 cm,95%CI:-1.80,-0.92;P = 0.001), and hip circumference(MD:-0.95 cm,95%CI:-1.55,-0.36;P = 0.002), triglycerides(MD:-30.6 mg/dl,95%CI:-61.0,-0.14;P = 0.049), fasting blood sugar (FBS) (MD:-5.72 mg/dl,95%CI:-11.25,-0.20;P = 0.042), and hemoglobin A1c(HbA1c)(MD:-0.28,95%CI:-0.35,-0.20;P = 0.001). Additionally, CM increased high-density lipoprotein-cholesterol levels(MD:2.03 mg/dl,95%CI:0.82,3.25;P = 0.001). However, we observed no significant effects of CM intake on total cholesterol levels, low-density lipoprotein-cholesterol, insulin, aspartate aminotransferase, and alanine aminotransferase. Conclusions The findings of our meta-analysis indicate that consuming CM can positively affect CMR factors. These benefits include improved anthropometric parameters, including body weight, body mass index, fat mass, waist circumference, and hip circumference, a reduction in glycemic parameters such as FBS and HbA1c, and an improvement in lipid profile. However, the study did not reveal any significant impact of CM consumption on insulin, total cholesterol, and liver enzyme levels. |
| format | Article |
| id | doaj-art-8b7ecef2aa9743c0a3e40e5c1860bcd3 |
| institution | Kabale University |
| issn | 1743-7075 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
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| series | Nutrition & Metabolism |
| spelling | doaj-art-8b7ecef2aa9743c0a3e40e5c1860bcd32025-08-20T03:42:37ZengBMCNutrition & Metabolism1743-70752025-08-0122111210.1186/s12986-025-00991-4Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysisMorteza Omrani0Mostafa Norouzzadeh1Hamid Ahmadirad2Mehrnaz Abbasi3Mitra Kazemi Jahromi4Farshad Teymoori5Minoo Hasan Rashedi6Seyedeh Tayebeh Rahideh7Hossein Farhadnejad8Parvin Mirmiran9Mohsen Khaleghian10Department of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesNutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesCollege of Human Sciences, Department of Nutritional Sciences, Auburn UniversityEndocrinology and Metabolism Research Center, Hormozgan University of Medical SciencesDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesNutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesNutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesDepartment of General Surgery, School of Medicine, Hazrat-Rasool General Hospital, Iran University of Medical SciencesAbstract Background Given the essential role of cardiometabolic risk factors in the global burden of chronic diseases, this study aimed to assess the potential of cornelian cherry(Cornus mas L.) in improving anthropometric parameters, lipid profile, glycemic indices, liver enzyme levels, and dietary intake of energy and macronutrients. Methods We conducted a systematic search of PubMed, Scopus, Web of Science, and the Cochrane Library for eligible randomized controlled trials(RCTs) published up to May 2025, with no restrictions on language or publication date. The weighted mean difference(WMD) and 95% confidence interval(95%CI) for each outcome were determined using a random-effects model. The certainty of the assessments was further examined using the GRADE assessment. Results Seven RCTs were included in the final analysis. Pooled effect size showed that Cornus mas L(CM) intake significantly reduced body weight (MD:-0.57 Kg,95%CI:-1.03,-0.12;P = 0.013), body mass index(MD:-0.38 kg/m2,95%CI:-0.52,-0.23;P = 0.001), fat mass (MD:-0.97%,95%CI:-1.53,-0.41;P = 0.001), waist circumference (MD:-1.36 cm,95%CI:-1.80,-0.92;P = 0.001), and hip circumference(MD:-0.95 cm,95%CI:-1.55,-0.36;P = 0.002), triglycerides(MD:-30.6 mg/dl,95%CI:-61.0,-0.14;P = 0.049), fasting blood sugar (FBS) (MD:-5.72 mg/dl,95%CI:-11.25,-0.20;P = 0.042), and hemoglobin A1c(HbA1c)(MD:-0.28,95%CI:-0.35,-0.20;P = 0.001). Additionally, CM increased high-density lipoprotein-cholesterol levels(MD:2.03 mg/dl,95%CI:0.82,3.25;P = 0.001). However, we observed no significant effects of CM intake on total cholesterol levels, low-density lipoprotein-cholesterol, insulin, aspartate aminotransferase, and alanine aminotransferase. Conclusions The findings of our meta-analysis indicate that consuming CM can positively affect CMR factors. These benefits include improved anthropometric parameters, including body weight, body mass index, fat mass, waist circumference, and hip circumference, a reduction in glycemic parameters such as FBS and HbA1c, and an improvement in lipid profile. However, the study did not reveal any significant impact of CM consumption on insulin, total cholesterol, and liver enzyme levels.https://doi.org/10.1186/s12986-025-00991-4Cornelian cherryCardiometabolic risk factorsAnthropometric parametersLipid profilesGlycemic indicesMeta-analysis |
| spellingShingle | Morteza Omrani Mostafa Norouzzadeh Hamid Ahmadirad Mehrnaz Abbasi Mitra Kazemi Jahromi Farshad Teymoori Minoo Hasan Rashedi Seyedeh Tayebeh Rahideh Hossein Farhadnejad Parvin Mirmiran Mohsen Khaleghian Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis Nutrition & Metabolism Cornelian cherry Cardiometabolic risk factors Anthropometric parameters Lipid profiles Glycemic indices Meta-analysis |
| title | Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis |
| title_full | Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis |
| title_fullStr | Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis |
| title_full_unstemmed | Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis |
| title_short | Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis |
| title_sort | cornelian cherry cardiometabolic health and dietary intake a grade assessed systematic review and meta analysis |
| topic | Cornelian cherry Cardiometabolic risk factors Anthropometric parameters Lipid profiles Glycemic indices Meta-analysis |
| url | https://doi.org/10.1186/s12986-025-00991-4 |
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