Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system

Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system

Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough for the treatment of hematological malignancies. However, to treat solid tumors and certain hematologic cancers, next-generation CAR-T cells require further genetic modifications to overcome some of the current limitations. Imp...

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Bibliographic Details
Main Authors: Aine O’Sullivan, Sarah Case, Aisling McCrudden, Emer Hackett, Louise Gallagher, Darren Martin, Gillian P. Johnson, Kirti Mahadik, Thomas Kienzle, Jude Kevin Lim, Aya Nashat, Kartik Srinivasan, Mark W. Lowdell, Lisa O’Flynn, Jamie Frankish
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CAR-T
genetic engineering
adoptive cell therapy
metabolism
cell avidity
cell cytotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124002055
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