The G-quadruplex ligand CX-5461: an innovative candidate for disease treatment

The G-quadruplex ligand CX-5461: an innovative candidate for disease treatment

Abstract The ribosomal DNA (rDNA) plays a vital role in regulating protein synthesis by ribosome biogenesis, essential for maintaining cellular growth, metabolism, and more. Cancer cells show a high dependence on ribosome biogenesis and exhibit elevated rDNA transcriptional activity. CX-5461, also k...

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Bibliographic Details
Main Authors: Hong-Xia Li, Yi-Meng He, Jing Fei, Man Guo, Chen Zeng, Pi-Jun Yan, Yong Xu, Gang Qin, Fang-Yuan Teng
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
CX-5461
Ribosomal RNA
Ribosome biogenesis
G-quadruplex
Cancer
Targeted therapy
Online Access:https://doi.org/10.1186/s12967-025-06473-8
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https://doi.org/10.1186/s12967-025-06473-8

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