Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy

Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy

ABSTRACT Gene therapy holds great potential for treating neurological disorders, but its implementation is limited by the challenge of developing a safe and effective delivery method to the central nervous system (CNS). Red blood cell‐derived extracellular vesicles (RBCEVs) have the potential to add...

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Main Authors: Brenda Wan Shing Lam, Melissa Tan, Chang Gao, Thach Tuan Pham, Lan Thi Ngoc Tran, Lan Ngoc Nguyen, Harwin Sidik, Matthias B. H. Lim, Anh Hong Le, Tram T. T. Nguyen, Nicole Lim, Lap Nguyen, Thuy Huong Nguyen, Yuin‐Han Loh, Muhammad Waqas Usman, Minh T. N. Le
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Extracellular Vesicles
Subjects:
central nervous system
extracellular vesicles
gene therapy
non‐human primates
plasmid delivery
safety
Online Access:https://doi.org/10.1002/jev2.70116
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https://doi.org/10.1002/jev2.70116

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