Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

Summary: Cardiomyocyte (CM) nuclei are constantly exposed to mechanical stress, but how they maintain their nuclear shape remains unknown. In this study, we found that ventricular CM nuclei acquire characteristic prominent spatial organizations of heterochromatin (SOH), which are disrupted by high-l...

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Main Authors: Keita Fujiwara, Tadashi Inoue, Aya Kimoto, Jiang Zixian, Keizo Tokuhiro, Yoshiki Yasukochi, Tomoya O. Akama, Chen-Leng Cai, Ichiro Shiojima, Hiroshi Kimura, Shige H. Yoshimura, Tomoyuki Nakamura, Maretoshi Hirai
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
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CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013998
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http://www.sciencedirect.com/science/article/pii/S2211124724013998

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