Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration
Fertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1506029/full |
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| _version_ | 1841551003765178368 |
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| author | Hiromitsu Tanaka Satona Ichihara |
| author_facet | Hiromitsu Tanaka Satona Ichihara |
| author_sort | Hiromitsu Tanaka |
| collection | DOAJ |
| description | Fertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lineages. In this study, the effects of rutin and quercetin on fertility and pregnancy rates were investigated by incorporating these compounds into the preculture medium for in vitro fertilization (IVF) or administering them orally to mice. The addition of rutin and quercetin to the preculture medium increased the IVF fertilization rate by more than twofold. Oral administration of rutin and quercetin to aged male and nulliparous female mice improved pregnancy outcomes. These findings have important implications for the non-invasive treatment of infertility. |
| format | Article |
| id | doaj-art-8ac9b9816e504b4ba47184219509f699 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-8ac9b9816e504b4ba47184219509f6992025-01-09T17:17:37ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15060291506029Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administrationHiromitsu TanakaSatona IchiharaFertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lineages. In this study, the effects of rutin and quercetin on fertility and pregnancy rates were investigated by incorporating these compounds into the preculture medium for in vitro fertilization (IVF) or administering them orally to mice. The addition of rutin and quercetin to the preculture medium increased the IVF fertilization rate by more than twofold. Oral administration of rutin and quercetin to aged male and nulliparous female mice improved pregnancy outcomes. These findings have important implications for the non-invasive treatment of infertility.https://www.frontiersin.org/articles/10.3389/fvets.2024.1506029/fullflavonoidinfertilityIVFpregnancyquercetinROS |
| spellingShingle | Hiromitsu Tanaka Satona Ichihara Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration Frontiers in Veterinary Science flavonoid infertility IVF pregnancy quercetin ROS |
| title | Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration |
| title_full | Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration |
| title_fullStr | Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration |
| title_full_unstemmed | Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration |
| title_short | Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration |
| title_sort | improving fertilization rates in ivf using rutin and quercetin in preculture medium or through oral administration |
| topic | flavonoid infertility IVF pregnancy quercetin ROS |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1506029/full |
| work_keys_str_mv | AT hiromitsutanaka improvingfertilizationratesinivfusingrutinandquercetininpreculturemediumorthroughoraladministration AT satonaichihara improvingfertilizationratesinivfusingrutinandquercetininpreculturemediumorthroughoraladministration |