Malignant Hyperthermia
Malignant hyperthermia (MH) is a life-threatening clinical syndrome caused by hypermetabolism involving skeletal muscle. MH is very rare, but it is one of the causes of death in the operating room. MH is an autosomal dominant disease and can be triggered when exposed to certain anesthetic drugs. Gen...
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| Format: | Article |
| Language: | English |
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Fakultas Kedokteran, Universitas Diponegoro
2025-07-01
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| Series: | JAI (Jurnal Anestesiologi Indonesia) |
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| Online Access: | https://ejournal.undip.ac.id/index.php/janesti/article/view/62676 |
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| _version_ | 1849336205574930432 |
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| author | Doni Fajri Nopian Hidayat Diana Masjkur |
| author_facet | Doni Fajri Nopian Hidayat Diana Masjkur |
| author_sort | Doni Fajri |
| collection | DOAJ |
| description | Malignant hyperthermia (MH) is a life-threatening clinical syndrome caused by hypermetabolism involving skeletal muscle. MH is very rare, but it is one of the causes of death in the operating room. MH is an autosomal dominant disease and can be triggered when exposed to certain anesthetic drugs. Genetic tests can help diagnose, but the gold standard is the caffeine halothane contracture test (CHCT). Initial symptoms are a decrease in pH and oxygen, as well as an increase in CO2, lactate, potassium, and temperature. The increase in lactate reflects tissue hypoxia. Dantrolene is an antidote to MH, by reducing calcium loss from the sarcoplasmic reticulum in skeletal muscle and returning metabolism to normal conditions. Immediate detection and treatment can improve MH outcomes. |
| format | Article |
| id | doaj-art-8ac30fb65f6e4c0a832c2cdb2b5f64d9 |
| institution | Kabale University |
| issn | 2337-5124 2089-970X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Fakultas Kedokteran, Universitas Diponegoro |
| record_format | Article |
| series | JAI (Jurnal Anestesiologi Indonesia) |
| spelling | doaj-art-8ac30fb65f6e4c0a832c2cdb2b5f64d92025-08-20T03:45:03ZengFakultas Kedokteran, Universitas DiponegoroJAI (Jurnal Anestesiologi Indonesia)2337-51242089-970X2025-07-0117216217210.14710/jai.v0i0.6267625985Malignant HyperthermiaDoni Fajri0Nopian Hidayat1Diana Masjkur2Faculty of Medicine, Universitas Riau, Pekanbaru, IndonesiaDepartment of Anesthesiology and Intensive Therapy, Universitas Riau, Pekanbaru, IndonesiaDepartment of Anesthesiology and Intensive Therapy, Universitas Riau, Pekanbaru, IndonesiaMalignant hyperthermia (MH) is a life-threatening clinical syndrome caused by hypermetabolism involving skeletal muscle. MH is very rare, but it is one of the causes of death in the operating room. MH is an autosomal dominant disease and can be triggered when exposed to certain anesthetic drugs. Genetic tests can help diagnose, but the gold standard is the caffeine halothane contracture test (CHCT). Initial symptoms are a decrease in pH and oxygen, as well as an increase in CO2, lactate, potassium, and temperature. The increase in lactate reflects tissue hypoxia. Dantrolene is an antidote to MH, by reducing calcium loss from the sarcoplasmic reticulum in skeletal muscle and returning metabolism to normal conditions. Immediate detection and treatment can improve MH outcomes.https://ejournal.undip.ac.id/index.php/janesti/article/view/62676anesthesiaautosomal dominantdantrolenehypermetabolismmalignant hyperthermia |
| spellingShingle | Doni Fajri Nopian Hidayat Diana Masjkur Malignant Hyperthermia JAI (Jurnal Anestesiologi Indonesia) anesthesia autosomal dominant dantrolene hypermetabolism malignant hyperthermia |
| title | Malignant Hyperthermia |
| title_full | Malignant Hyperthermia |
| title_fullStr | Malignant Hyperthermia |
| title_full_unstemmed | Malignant Hyperthermia |
| title_short | Malignant Hyperthermia |
| title_sort | malignant hyperthermia |
| topic | anesthesia autosomal dominant dantrolene hypermetabolism malignant hyperthermia |
| url | https://ejournal.undip.ac.id/index.php/janesti/article/view/62676 |
| work_keys_str_mv | AT donifajri malignanthyperthermia AT nopianhidayat malignanthyperthermia AT dianamasjkur malignanthyperthermia |