Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss

Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss

Abstract Background Diabetes-associated cognitive dysfunction, characterized by hippocampal synaptic loss as an early pathological feature, seriously threatens patients’ quality of life. Synapses are dynamic structures, and hormones play important roles in modulating the formation and elimination of...

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Bibliographic Details
Main Authors: Jiaxuan Jiang, Pengzi Zhang, Yue Yuan, Xiang Xu, Tianyu Wu, Zhou Zhang, Jin Wang, Yan Bi
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Subjects:
Prolactin
Diabetes mellitus
Cognitive dysfunction
Microglia
Phagocytosis
Synapses
Online Access:https://doi.org/10.1186/s12974-024-03289-z
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https://doi.org/10.1186/s12974-024-03289-z

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