Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome

Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome

Abstract Errors in chromosome segregation during gametogenesis, such as nondisjunction (NDJ) errors, have severe consequences in human reproduction, and a better understanding of their etiology is of fundamental interest in genetics. Mapping NDJ errors to meiotic/mitotic stages typically requires pr...

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Main Authors: Zhenhua Li, Wenjian Yang, Gang Wu, Ti-Cheng Chang, Zhongshan Cheng, Meenakshi Devidas, Mary Shago, Andrew J. Carroll, Nyla A. Heerema, Julie M. Gastier-Foster, Brent L. Wood, Lauren Sanclemente, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Eleanor Feingold, Tracie C. Rosser, Emily G. Allen, Stephanie L. Sherman, Karen R. Rabin, Philip J. Lupo, Jun J. Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61413-w
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https://doi.org/10.1038/s41467-025-61413-w

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