Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone
Background: The treatment for patients with cervical low-grade squamous intraepithelial lesion (LSIL) and type 3 transformation zone (TZ) had limitations. The aim of this study was to compare the efficacy of new approach 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and observation in those p...
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| Format: | Article |
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002500211X |
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| author | Ruizhe Chen Junfen Xu Chun Ye Lingjia Lu Ying Li Lingfang Wang Xiaodong Cheng Yunfeng Fu |
| author_facet | Ruizhe Chen Junfen Xu Chun Ye Lingjia Lu Ying Li Lingfang Wang Xiaodong Cheng Yunfeng Fu |
| author_sort | Ruizhe Chen |
| collection | DOAJ |
| description | Background: The treatment for patients with cervical low-grade squamous intraepithelial lesion (LSIL) and type 3 transformation zone (TZ) had limitations. The aim of this study was to compare the efficacy of new approach 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and observation in those patients. Methods: This study retrospectively analyzed data from 236 patients (aged 25–45 years) with cervical LSIL and type 3 TZ. Participants were divided into ALA-PDT and observation groups, and were followed up for 1-year post-diagnosis. Outcomes were compared and factors influencing LSIL regression and human papillomavirus (HPV) clearance were analyzed. Results: The LSIL regression rate was 89.8 % in the ALA-PDT group, significantly higher than 68.4 % in the observation group (P < 0.05). The ALA-PDT group demonstrated a significantly higher HPV clearance rate of 69.5 % compared to 39.0 % in the observation group (P < 0.05). No significant correlation was found between baseline clinical characteristics and LSIL regression or HPV clearance in either group. Conclusion: ALA-PDT is effective in promoting LSIL regression and HPV clearance. ALA-PDT may be considered as a viable treatment option for women with type 3 TZ, persistent LSIL and high-risk HPV infection, The efficacy of ALA-PDT is not affected by clinical characteristics, suggesting its benefit for patients with various clinical risk factors. |
| format | Article |
| id | doaj-art-8a24cc95d72c4773a43d6b5db2be9688 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-8a24cc95d72c4773a43d6b5db2be96882025-08-20T04:00:40ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410467910.1016/j.pdpdt.2025.104679Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zoneRuizhe Chen0Junfen Xu1Chun Ye2Lingjia Lu3Ying Li4Lingfang Wang5Xiaodong Cheng6Yunfeng Fu7Medical center for cervical diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaMedical center for cervical diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaMedical center for cervical diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaMedical center for cervical diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Corresponding authors at: Women’s Hospital, Zhejiang University School of Medicine, Xueshi Road No.1, Hangzhou, 310006, China.Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, ChinaMedical center for cervical diseases, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Corresponding authors at: Women’s Hospital, Zhejiang University School of Medicine, Xueshi Road No.1, Hangzhou, 310006, China.Background: The treatment for patients with cervical low-grade squamous intraepithelial lesion (LSIL) and type 3 transformation zone (TZ) had limitations. The aim of this study was to compare the efficacy of new approach 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and observation in those patients. Methods: This study retrospectively analyzed data from 236 patients (aged 25–45 years) with cervical LSIL and type 3 TZ. Participants were divided into ALA-PDT and observation groups, and were followed up for 1-year post-diagnosis. Outcomes were compared and factors influencing LSIL regression and human papillomavirus (HPV) clearance were analyzed. Results: The LSIL regression rate was 89.8 % in the ALA-PDT group, significantly higher than 68.4 % in the observation group (P < 0.05). The ALA-PDT group demonstrated a significantly higher HPV clearance rate of 69.5 % compared to 39.0 % in the observation group (P < 0.05). No significant correlation was found between baseline clinical characteristics and LSIL regression or HPV clearance in either group. Conclusion: ALA-PDT is effective in promoting LSIL regression and HPV clearance. ALA-PDT may be considered as a viable treatment option for women with type 3 TZ, persistent LSIL and high-risk HPV infection, The efficacy of ALA-PDT is not affected by clinical characteristics, suggesting its benefit for patients with various clinical risk factors.http://www.sciencedirect.com/science/article/pii/S157210002500211X5-aminolevulinic acid photodynamic therapyLow-grade squamous intraepithelial lesionHuman papillomavirusType 3 transformation zone |
| spellingShingle | Ruizhe Chen Junfen Xu Chun Ye Lingjia Lu Ying Li Lingfang Wang Xiaodong Cheng Yunfeng Fu Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone Photodiagnosis and Photodynamic Therapy 5-aminolevulinic acid photodynamic therapy Low-grade squamous intraepithelial lesion Human papillomavirus Type 3 transformation zone |
| title | Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone |
| title_full | Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone |
| title_fullStr | Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone |
| title_full_unstemmed | Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone |
| title_short | Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone |
| title_sort | efficacy of 5 aminolevulinic acid photodynamic therapy versus observation for cervical low grade squamous intraepithelial lesion with type 3 transformation zone |
| topic | 5-aminolevulinic acid photodynamic therapy Low-grade squamous intraepithelial lesion Human papillomavirus Type 3 transformation zone |
| url | http://www.sciencedirect.com/science/article/pii/S157210002500211X |
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