Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets

Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets

Oral bile acids, particularly hyodeoxycholic acid (HDCA), serve as critical drivers for gut microbial community maturation in mice. In the first study, Cy5-labeled HDCA combined with fluorescence imaging revealed rapid gastrointestinal transit of HDCA in piglets, contrasting with its delayed absorpt...

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Bibliographic Details
Main Authors: Jie Chong, Yongming Zhou, Zhi Li, Xiaokai Li, Jinwei Zhang, Haoran Cao, Jideng Ma, Liangpeng Ge, Hang Zhong, Jing Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Veterinary Science
Subjects:
hyodeoxycholic acid
gut microbiota
intestinal barrier function
bile acid metabolism
TGR5 signal pathway
piglets
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1610956/full
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