DNA Damage Response Regulation Alleviates Neuroinflammation in a Mouse Model of α-Synucleinopathy

DNA Damage Response Regulation Alleviates Neuroinflammation in a Mouse Model of α-Synucleinopathy

Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by the degeneration of dopaminergic neurons in the substantia nigra, leading to decreased dopamine levels in the striatum and causing a range of motor and non-motor impairments. Although the molecular mechanisms driving PD p...

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Bibliographic Details
Main Authors: Sazzad Khan, Himanshi Singh, Jianfeng Xiao, Mohammad Moshahid Khan
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
Parkinson’s disease
AZD1390
DNA damage
α-synuclein
behavioral functions
inflammation
Online Access:https://www.mdpi.com/2218-273X/15/7/907
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