Selectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure

Selectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure

Abstract Acute liver failure (ALF) is a hepatology emergency with rapid hepatic destruction, multiple organ failures, and high mortality. Despite decades of research, established ALF has minimal therapeutic options. Here, we report that the small bioactive compound SCM-198 increases the survival of...

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Main Authors: Rui Wang, Youwei Chen, Jiazhen Han, Huikang Ye, Huiran Yang, Qianyan Li, Yizhen He, Boyu Ma, Junjie Zhang, Yanli Ge, Zhe Wang, Bo Sun, Huahua Liu, Liming Cheng, Zhirong Wang, Gufa Lin
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55295-7
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https://doi.org/10.1038/s41467-024-55295-7

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