RBBP6‐Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease

RBBP6‐Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease

Abstract Diabetic Kidney Disease (DKD), a major precursor to end‐stage renal disease, involves mitochondrial dysfunction in proximal renal tubular cells (PTCs), contributing to its pathogenesis. Estrogen‐related receptor α (ERRα) is essential for mitochondrial integrity in PTCs, yet its regulation i...

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Main Authors: Hongtu Hu, Jijia Hu, Zhaowei Chen, Keju Yang, Zijing Zhu, Yiqun Hao, Zongwei Zhang, Weiwei Li, Zhuan Peng, Yun Cao, Xiaoling Sun, Fangcheng Zhang, Qingjia Chi, Guohua Ding, Wei Liang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
diabetic kidney disease
estrogen‐related receptor α
mitochondrial dysfunction
proximal renal tubular cells
RBBP6, ubiquitination
Online Access:https://doi.org/10.1002/advs.202405153
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https://doi.org/10.1002/advs.202405153

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