Drug repurposing reveals posaconazole as a CYP11A1 inhibitor enhancing anti-tumor immunity

Drug repurposing reveals posaconazole as a CYP11A1 inhibitor enhancing anti-tumor immunity

Summary: Steroid hormones regulate cell physiology and immune function, with dysregulated steroidogenesis promoting cancer progression by supporting tumor growth and suppressing anti-tumor immunity. Targeting CYP11A1, the first and rate-limiting enzyme in steroid biosynthesis, has shown promise in c...

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Bibliographic Details
Main Authors: Jhuma Pramanik, Sanu Korumadathil Shaji, Megan Zaman, Bethany Brown, Baojie Zhang, Yumi Yamashita-Kanemaru, Natalie Z.M. Homer, Hosni A.M. Hussein, Qiuchen Zhao, Klaus Okkenhaug, Rahul Roychoudhuri, Abhik Mukhopadhyay, Bidesh Mahata
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Pharmacology
Natural sciences
Biological sciences
Systems biology
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007497
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