Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells

Abstract Non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) almost invariably relapse in the long term, due to the emergence of subpopulations of resistant cells. Through a DNA barcoding approach, we show that the clinic...

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Main Authors: Lisa Brunet, David Alexandre, Jiyoung Lee, Maria del Mar Blanquer-Rosselló, David Bracquemond, Alexis Guernet, Houssein Chhouri, Mathilde Goupil, Zoulika Kherrouche, Arnaud Arabo, Maicol Mancini, Dorthe Cartier, Shen Yao, David Godefroy, Julie Dehedin, Jian-Rong Li, Céline Duparc, Philippe Jamme, Audrey Vinchent, Caroline Bérard, David Tulasne, Sabrina Arena, Alberto Bardelli, Chao Cheng, Byoung Chul Cho, Olivier Wurtz, Cédric Coulouarn, Antonio Maraver, Stuart A. Aaronson, Alexis B. Cortot, Youssef Anouar, Luca Grumolato
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61788-w
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https://doi.org/10.1038/s41467-025-61788-w

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