Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis
BackgroundThe prognostic significance of the Naples prognostic score (NPS) in colorectal cancer remains uncertain. This study aims to investigate the correlation between the pretreatment NPS and long-term oncological outcomes in patients with colorectal cancer.MethodsA comprehensive literature searc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1498854/full |
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| author | Hui Liu Dailiang Zhu Dequan Jiang Huayang Pang Xiaolian Yang |
| author_facet | Hui Liu Dailiang Zhu Dequan Jiang Huayang Pang Xiaolian Yang |
| author_sort | Hui Liu |
| collection | DOAJ |
| description | BackgroundThe prognostic significance of the Naples prognostic score (NPS) in colorectal cancer remains uncertain. This study aims to investigate the correlation between the pretreatment NPS and long-term oncological outcomes in patients with colorectal cancer.MethodsA comprehensive literature search of electronic databases, including PubMed, Embase, and Web of Science, was conducted up to July 1st, 2024. The primary outcomes assessed were survival outcomes. Subgroup analysis and sensitivity analysis were performed during the pooled analysis.ResultsEight studies including 2571 patients were included. The pooled results indicated that patients in the high NPS group exhibited significantly worse overall survival (HR= 2.08 95%CI: 1.74-2.48; P<0.01; I2 = 0%) and disease-free survival (HR=2.03; 95%CI: 1.49-2.77; P<0.01; I2 = 30%). Notably, the prognostic significance of NPS on both overall survival and disease-free survival was consistent across different geographical regions, tumor stages, and primary treatments examined in this study. Furthermore, sensitivity analyses confirmed the robustness of these combined results.ConclusionThe pretreatment NPS could serve as a valuable biomarker for predicting long-term oncological outcomes in patients diagnosed with colorectal cancer. |
| format | Article |
| id | doaj-art-88f379d43a344597a68aae06b0b04ce7 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-88f379d43a344597a68aae06b0b04ce72025-01-07T05:24:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14988541498854Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysisHui Liu0Dailiang Zhu1Dequan Jiang2Huayang Pang3Xiaolian Yang4Department of Gastrointestinal Surgery, Chongqing University Jiangjin Hospital, Chongqing, ChinaDepartment of Anorectal Surgery, Chongqing University Jiangjin Hospital, Chongqing, ChinaDepartment of Gastrointestinal Surgery, Chongqing University Jiangjin Hospital, Chongqing, ChinaDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, ChinaDepartment of Anorectal Surgery, Chongqing University Jiangjin Hospital, Chongqing, ChinaBackgroundThe prognostic significance of the Naples prognostic score (NPS) in colorectal cancer remains uncertain. This study aims to investigate the correlation between the pretreatment NPS and long-term oncological outcomes in patients with colorectal cancer.MethodsA comprehensive literature search of electronic databases, including PubMed, Embase, and Web of Science, was conducted up to July 1st, 2024. The primary outcomes assessed were survival outcomes. Subgroup analysis and sensitivity analysis were performed during the pooled analysis.ResultsEight studies including 2571 patients were included. The pooled results indicated that patients in the high NPS group exhibited significantly worse overall survival (HR= 2.08 95%CI: 1.74-2.48; P<0.01; I2 = 0%) and disease-free survival (HR=2.03; 95%CI: 1.49-2.77; P<0.01; I2 = 30%). Notably, the prognostic significance of NPS on both overall survival and disease-free survival was consistent across different geographical regions, tumor stages, and primary treatments examined in this study. Furthermore, sensitivity analyses confirmed the robustness of these combined results.ConclusionThe pretreatment NPS could serve as a valuable biomarker for predicting long-term oncological outcomes in patients diagnosed with colorectal cancer.https://www.frontiersin.org/articles/10.3389/fonc.2024.1498854/fullcolorectal cancernaples prognostic scoreoverall survivaldisease-free survivalmeta-analysis |
| spellingShingle | Hui Liu Dailiang Zhu Dequan Jiang Huayang Pang Xiaolian Yang Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis Frontiers in Oncology colorectal cancer naples prognostic score overall survival disease-free survival meta-analysis |
| title | Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis |
| title_full | Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis |
| title_fullStr | Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis |
| title_short | Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis |
| title_sort | prognostic value of the pretreatment naples prognostic score in patients with colorectal cancer a systematic review and meta analysis |
| topic | colorectal cancer naples prognostic score overall survival disease-free survival meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1498854/full |
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