HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS
Objective – to study the presence and significance of human papillomavirus and Epstein-Barr virus in the development of chronic hyperplastic laryngitis and evaluate the effectiveness of immunomodulating therapy in the treatment of the disease. Methods. Thirty men with chronic hyperplastic laryngiti...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2019-12-01
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| Series: | Медицина в Кузбассе |
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| Online Access: | http://mednauki.ru/index.php/MK/article/view/407 |
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| author | Виктор Дмитриевич Осипов Галина Северьевна Суржикова Сергей Николаевич Филимонов Сатеник Аршавиловна Клочкова-Абельянц |
| author_facet | Виктор Дмитриевич Осипов Галина Северьевна Суржикова Сергей Николаевич Филимонов Сатеник Аршавиловна Клочкова-Абельянц |
| author_sort | Виктор Дмитриевич Осипов |
| collection | DOAJ |
| description | Objective – to study the presence and significance of human papillomavirus and Epstein-Barr virus in the development of chronic hyperplastic laryngitis and evaluate the effectiveness of immunomodulating therapy in the treatment of the disease.
Methods. Thirty men with chronic hyperplastic laryngitis aged 30 to 70 years were examined. The comparison group consisted of 30 healthy men over the age of 29 years. The determination of human papillomavirus was carried out by polymerase chain reaction. Antibodies to Epstein-Barr virus antigens were investigated by enzyme immunoassay.
Results. Among patients with chronic hyperplastic laryngitis, HPV infection was 50 %: HPV was detected in 15 of the 30 samples studied. At the same time, HPV of type 11 was detected in 3 patients; in 12 cases, human papillomaviruses of high oncogenic risk were detected – genotypes 16, 18, 31, 31. Indirect laryngoscopy revealed diffuse hyperplasia of all sections of the laryngeal mucosa in 9 (30 %) patients with chronic hepatitis C and there was uneven mucosal hyperplasia and its hyperemia in 21 (70 %). Antibodies to capsid and early Epstein-Barr virus antigens were tested in 21 patients with chronic hepatitis C (70 %).
Conclusions. The detection of HPV of high oncogenic risk in chronic hepatitis C, the presence of high titers of specific antibodies characterizing the immune response to the Epstein-Barr virus, indicates the activation of the virus in the body of patients with chronic hyperplastic laryngitis. Conducted comprehensive treatment with the inclusion of an inducer of interferon - cycloferon gives a visible clinical effect in the treatment of this category of patients. |
| format | Article |
| id | doaj-art-8885ee9e75e545cdaa06a0b5776bd4c7 |
| institution | Kabale University |
| issn | 1819-0901 2588-0411 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Медицина в Кузбассе |
| spelling | doaj-art-8885ee9e75e545cdaa06a0b5776bd4c72025-08-20T03:56:58ZrusThe Publishing House Medicine and EnlightenmentМедицина в Кузбассе1819-09012588-04112019-12-011844345368HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITISВиктор Дмитриевич Осипов0Галина Северьевна Суржикова1Сергей Николаевич Филимонов2Сатеник Аршавиловна Клочкова-Абельянц3НГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкНГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкФГБНУ НИИ КПГПЗ, г. НовокузнецкНГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкObjective – to study the presence and significance of human papillomavirus and Epstein-Barr virus in the development of chronic hyperplastic laryngitis and evaluate the effectiveness of immunomodulating therapy in the treatment of the disease. Methods. Thirty men with chronic hyperplastic laryngitis aged 30 to 70 years were examined. The comparison group consisted of 30 healthy men over the age of 29 years. The determination of human papillomavirus was carried out by polymerase chain reaction. Antibodies to Epstein-Barr virus antigens were investigated by enzyme immunoassay. Results. Among patients with chronic hyperplastic laryngitis, HPV infection was 50 %: HPV was detected in 15 of the 30 samples studied. At the same time, HPV of type 11 was detected in 3 patients; in 12 cases, human papillomaviruses of high oncogenic risk were detected – genotypes 16, 18, 31, 31. Indirect laryngoscopy revealed diffuse hyperplasia of all sections of the laryngeal mucosa in 9 (30 %) patients with chronic hepatitis C and there was uneven mucosal hyperplasia and its hyperemia in 21 (70 %). Antibodies to capsid and early Epstein-Barr virus antigens were tested in 21 patients with chronic hepatitis C (70 %). Conclusions. The detection of HPV of high oncogenic risk in chronic hepatitis C, the presence of high titers of specific antibodies characterizing the immune response to the Epstein-Barr virus, indicates the activation of the virus in the body of patients with chronic hyperplastic laryngitis. Conducted comprehensive treatment with the inclusion of an inducer of interferon - cycloferon gives a visible clinical effect in the treatment of this category of patients.http://mednauki.ru/index.php/MK/article/view/407хронический гиперпластический ларингитвирус папилломы человекавирус эпштейна-баррадиагностикалечение |
| spellingShingle | Виктор Дмитриевич Осипов Галина Северьевна Суржикова Сергей Николаевич Филимонов Сатеник Аршавиловна Клочкова-Абельянц HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS Медицина в Кузбассе хронический гиперпластический ларингит вирус папилломы человека вирус эпштейна-барра диагностика лечение |
| title | HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS |
| title_full | HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS |
| title_fullStr | HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS |
| title_full_unstemmed | HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS |
| title_short | HUMAN PAPILLOMA VIRUS AND EPSTEIN-BARR VIRUS IN THE DIAGNOSIS AND CLINICAL COURSE OF CHRONIC HYPERPLASTIC LARYNGITIS |
| title_sort | human papilloma virus and epstein barr virus in the diagnosis and clinical course of chronic hyperplastic laryngitis |
| topic | хронический гиперпластический ларингит вирус папилломы человека вирус эпштейна-барра диагностика лечение |
| url | http://mednauki.ru/index.php/MK/article/view/407 |
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