Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study
Objective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.Design, setting and participants In this pros...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/1/e085238.full |
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| author | Axel C Carlsson Caroline Heijl Ardavan M Khoshnood Alexander Yaghoubi Per Erik Wändell Torgny Wessman |
| author_facet | Axel C Carlsson Caroline Heijl Ardavan M Khoshnood Alexander Yaghoubi Per Erik Wändell Torgny Wessman |
| author_sort | Axel C Carlsson |
| collection | DOAJ |
| description | Objective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.Design, setting and participants In this prospective observational study, 723 hospitalised patients who visited the emergency department at Skåne University Hospital, Sweden, between 2013 and 2018 were included. Of these, 276 had a history of CHF. The association between endostatin levels and 1 month and 3-month mortality was evaluated, stratified by whether patients had a history of CHF or not.Results Patients with prior CHF had higher endostatin levels, higher short-term mortality and were more likely to have CHF as discharge diagnosis. In a fully adjusted model, endostatin was independently associated with 3-month mortality (HR=1.01 per 1 ng/mL increment of endostatin; 95% CI 1.00 to 1.02; p=0.016). No evidence of association was identified with 1-month mortality.Conclusions Endostatins are potential biomarkers for 3 months’ mortality in patients hospitalised with CHF seeking emergency care with acute dyspnoea. Further studies are needed in different settings to assess the predictive value of endostatins in patients with CHF. |
| format | Article |
| id | doaj-art-88699f81769947699a3dbb006206380d |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-88699f81769947699a3dbb006206380d2025-01-15T01:30:09ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-085238Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational studyAxel C Carlsson0Caroline Heijl1Ardavan M Khoshnood2Alexander Yaghoubi3Per Erik Wändell4Torgny Wessman57Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, SwedenDepartment of Cardiology, Skåne University Hospital, Malmö, Skåne, SwedenEmergency Medicine, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, SwedenEmergency Department, Skåne University Hospital, Malmo, Skåne, SwedenKarolinska Institute, Stockholm, Stockholm, SwedenEmergency Department, Skåne University Hospital, Malmo, Skåne, SwedenObjective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.Design, setting and participants In this prospective observational study, 723 hospitalised patients who visited the emergency department at Skåne University Hospital, Sweden, between 2013 and 2018 were included. Of these, 276 had a history of CHF. The association between endostatin levels and 1 month and 3-month mortality was evaluated, stratified by whether patients had a history of CHF or not.Results Patients with prior CHF had higher endostatin levels, higher short-term mortality and were more likely to have CHF as discharge diagnosis. In a fully adjusted model, endostatin was independently associated with 3-month mortality (HR=1.01 per 1 ng/mL increment of endostatin; 95% CI 1.00 to 1.02; p=0.016). No evidence of association was identified with 1-month mortality.Conclusions Endostatins are potential biomarkers for 3 months’ mortality in patients hospitalised with CHF seeking emergency care with acute dyspnoea. Further studies are needed in different settings to assess the predictive value of endostatins in patients with CHF.https://bmjopen.bmj.com/content/15/1/e085238.full |
| spellingShingle | Axel C Carlsson Caroline Heijl Ardavan M Khoshnood Alexander Yaghoubi Per Erik Wändell Torgny Wessman Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study BMJ Open |
| title | Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study |
| title_full | Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study |
| title_fullStr | Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study |
| title_full_unstemmed | Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study |
| title_short | Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study |
| title_sort | association between endostatin and mortality in patients with acute dyspnoea with or without congestive heart failure a single centre prospective observational study |
| url | https://bmjopen.bmj.com/content/15/1/e085238.full |
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