The impact of bacterial purine metabolism on antibiotic efficacy

Abstract Metabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and resistant phenotypes. However, whether high or low pu...

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Bibliographic Details
Main Authors: Claire E. Stevens, Ashley T. Deventer, Joanne K. Hobbs
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Antimicrobials and Resistance
Online Access:https://doi.org/10.1038/s44259-025-00139-7
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