Serotype-specific host proteome remodeling in human foreskin fibroblasts during lytic HSV-1 and HSV-2 infection

Serotype-specific host proteome remodeling in human foreskin fibroblasts during lytic HSV-1 and HSV-2 infection

Abstract Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) exhibit distinct clinical manifestations, yet the molecular basis of their serotype-specific pathogenicity remains unclear. This study presents a comparative proteomic analysis of human foreskin fibroblast (HFF-1) cells during lytic HSV...

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Bibliographic Details
Main Authors: Xiaohong Pan, Jiaxin Xie, Zhidan Zhang, Xiaomei Guo, Jixiong Li, Di Lin, Ying Qian, Jingwen Xu, Yunzhang Hu, Jiandong Shi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
HSV-1
HSV-2
Proteomics
Viral pathogenesis
Metabolic reprogramming
Antiviral immunity
Online Access:https://doi.org/10.1186/s12985-025-02803-w
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https://doi.org/10.1186/s12985-025-02803-w

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