MARCH8 promotes the proteasomal degradation of foot-and-mouth disease virus VP1, VP2, and VP3 to negatively regulate viral replication

MARCH8 promotes the proteasomal degradation of foot-and-mouth disease virus VP1, VP2, and VP3 to negatively regulate viral replication

Abstract The host cell membrane-associated RING-CH8 protein (MARCH8) functions as an antiviral host factor by targeting viral envelope glycoproteins. Foot-and-mouth disease virus (FMDV) is a non-enveloped, positive-sense, single-stranded RNA virus. The potential impact of MARCH8 on FMDV replication...

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Bibliographic Details
Main Authors: Mengge Yin, Xiangmin Li, Min Zhang, Qiongqiong Zhao, Haoyuan Wang, Huiyan Zhang, Zengjun Lu, Ping Qian
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Veterinary Research
Subjects:
Membrane-associated RING-CH8 protein
foot-and-mouth disease virus
restriction factor
proteasomal degradation
K33-linked polyubiquitination
Online Access:https://doi.org/10.1186/s13567-025-01521-z
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https://doi.org/10.1186/s13567-025-01521-z

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