Generation and characterization of genetically modified pigs with GGTA1/β4GalNT2/CMAH knockout and human CD55/CD47 expression for xenotransfusion studies

Generation and characterization of genetically modified pigs with GGTA1/β4GalNT2/CMAH knockout and human CD55/CD47 expression for xenotransfusion studies

Abstract Pig red blood cells (pRBCs) represent a promising alternative to address the shortage in transfusion medicine. Nonetheless, a major obstacle to their clinical implementation is immunological rejection. In this study, we generated transgenic pigs expressing human CD47 (hCD47) and CD55 (hCD55...

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Bibliographic Details
Main Authors: Bin Fang, Chunting Wang, Yilin Yuan, Xiaorui Liu, Lili Shi, Lin Li, Ying Wang, Yifan Dai, Haiyuan Yang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Gene editing
Transgenic pigs
Xenotransfusion
Online Access:https://doi.org/10.1038/s41598-024-81730-2
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