SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts

Abstract Mammalian genomes are subdivided into euchromatic A compartments that contain mostly active chromatin, and inactive, heterochromatic B compartments. However, it is not well understood how A and B genome compartments are established and maintained. Here we study SMCHD1, an SMC-like protein b...

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Bibliographic Details
Main Authors: Zhijun Huang, Wei Cui, Ishara Ratnayake, Kristin L. Gallik, Lorna Cohen, Rabi Tawil, Gerd P. Pfeifer
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62211-0
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