Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

The alpha-synuclein (αSyn) seeding ampliﬁcation assay (SAA) that allows the generation of disease-speciﬁc in vitro seeded ﬁbrils (SAA ﬁbrils) is used as a research tool to study the connection between the structure of αSyn fibrils, cellular seeding/spreading, and the clinicopathological manifestatio...

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Bibliographic Details
Main Authors:	Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-11-01
Series:	eLife
Subjects:	Alpha-synuclein seeded amplification assay strains Synucleinopathies
Online Access:	https://elifesciences.org/articles/92775
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