Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

The alpha-synuclein (αSyn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of αSyn fibrils, cellular seeding/spreading, and the clinicopathological manifestatio...

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Bibliographic Details
Main Authors: Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/92775
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