CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors

CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors

BackgroundAdaptive human natural killer (NK) cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection. They are characterized by CD94/NKG2C expression, a mature CD57+KIR+NKG2A– phenotype, a prolonged lifespan, and remarkable antitumor functions. In light of these features, ada...

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Bibliographic Details
Main Authors: Chiara Giordano, Simona Carlomagno, Michela Falco, Claudia Cantoni, Massimo Vitale, Ignazio Caruana, Johannes Dirks, Alberto Serio, Letizia Muccio, Giulia Bartalucci, Alessandra Bo, Franco Locatelli, Cristina Bottino, Simona Sivori, Mariella Della Chiesa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
adaptive NK cells
CD94/NKG2C
expansion
monoclonal antibody
immunotherapy
ADCC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1481745/full
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