Factor H-related 2 levels dictate FHR dimer composition

Factor H-related 2 levels dictate FHR dimer composition

Abstract Factor H-related (FHR) protein 1 and 2 form dimers resulting in FHR-1 and -2 homodimers, and FHR-1/2 heterodimers. Dimerization is hypothesized to further increase their antagonistic function with complement regulator factor H (FH). So far, only FHR-1 homodimers and FHR-1/2 heterodimers cou...

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Main Authors: Bert R. J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Maaike Derlagen, Nadia C. H. Keijzer, Mark Hoogenboezem, Taco W. Kuijpers, Richard B. Pouw
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Complement system
FHR-1
FHR-2
Dimerization
Online Access:https://doi.org/10.1038/s41598-025-94064-4
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https://doi.org/10.1038/s41598-025-94064-4

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