EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma

EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma

Abstract Synovial sarcoma (SS) is driven by a unique t(18;X) chromosomal translocation resulting in expression of the SS18-SSX fusion oncoprotein, a transcriptional regulator with both activating and repressing functions. However, the manner in which SS18-SSX contributes to the development of SS is...

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Main Authors: Muhammad Mushtaq, Judit Liaño-Pons, Jiansheng Wang, Mohammad Alzrigat, Ye Yuan, María Victoria Ruiz-Pérez, Yi Chen, Elena Kashuba, Felix Haglund de Flon, Bertha Brodin, Marie Arsenian-Henriksson
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07176-6
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https://doi.org/10.1038/s41419-024-07176-6

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