System‐wide optimization of an orthogonal translation system with enhanced biological tolerance

Abstract Over the past two decades, synthetic biological systems have revolutionized the study of cellular physiology. The ability to site‐specifically incorporate biologically relevant non‐standard amino acids using orthogonal translation systems (OTSs) has proven particularly useful, providing unp...

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Bibliographic Details
Main Authors: Kyle Mohler, Jack M Moen, Svetlana Rogulina, Jesse Rinehart
Format: Article
Language:English
Published: Springer Nature 2023-07-01
Series:Molecular Systems Biology
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Online Access:https://doi.org/10.15252/msb.202110591
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